SHAPE Analysis of 5’ Untranslated Region of Mouse Hepatitis Virus
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Software called SHAPE finder was used to analyze the secondary structure 5’ UTR of MHV. This study was the first time this software has been used for MHV, and if the previous procedures are followed, we will have high resolution results of the RNA secondary structures. Currently, the replication and pathogenesis of MHV is incompletely understood in part because of a lack of an accurate determination of its RNA secondary structure. This will help us better understand its course of proliferation. Since MHV is a good model for other coronaviruses and structures important for replication are most often conserved amongst closely related viruses, this information may provide a better understanding of the replication of related coronaviruses such as SARS-coronavirus.
Masud, Faryal 1989- (2011). SHAPE Analysis of 5’ Untranslated Region of Mouse Hepatitis Virus. Honors and Undergraduate Research. Available electronically from