Browsing by Subject "epigenetics"
Now showing items 1-17 of 17
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Alternative splicing is a eukaryotic mRNA processing mechanism in which exons within a pre-RNA transcript are joined differently or skipped entirely, yielding multiple protein isoforms from a single gene. This project ...
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(Texas A&M University, 2004-09-30)Epigenetic regulation is a mechanism by which heritable changes in gene expression are controlled by chromatin status rather than primary DNA sequence. Changes in chromatin structure affect accessibility of DNA elements ...
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(2016-01-13)During colon cancer development, epigenetic alterations contribute to the dysregulation of major cellular functions and signaling pathways. Recent evidence suggests that nutritionally chemoprotective components that influence ...
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(2012-10-19)During early mammalian embryogenesis, the embryonic genome undergoes critical reprogramming events that include changes in both DNA methylation and histone modifications necessary to control chromatin structure and thus, ...
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(2022-07-05)Seasonal animal migration is a common adaptive response to environmental perturbations. However, the molecular processes in the brain regulating physiological and behavioral migratory traits are largely unknown. To address ...
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(Texas A&M University, 2004-11-15)The advent of somatic cell nuclear transfer in cattle has provided the opportunity for researchers to generate genetically identical animals as well as animals that possess precise genetic modifications for agriculture and ...
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(2017-12-09)In recent years, there has been increased interest into better understanding how environmental In recent years, there has been increased interest into better understanding how environmental exposures influence the long-term ...
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(2022-12-12)This dissertation project evaluated whether methylation of DNA of peripheral white blood cells (WBC) is predictive of methylation of DNA in components of the hypothalamic-pituitary-adrenal (HPA) axis of mature Brahman cows; ...
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(2019-04-08)Two major hallmarks of cancer cells are their ability to sustain proliferative signaling and evade growth suppressors. This can occur when the cell loses transcriptional control of key growth genes through epigenetic ...
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(2011-08-08)Mesenchymal stem cells are more and more widely used in tissue engineering due to their pluripotency and no relative ethical problems. Traditional characterization techniques to detect mesenchymal stem cell states include ...
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(2013-06-26)Separate domestication events and strong selective pressures have created diverse phenotypes among existing cattle populations; however, the genetic determinants underlying most phenotypes are currently unknown. Bos taurus ...
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(2014-05-01)Accelerated body weight gain during the juvenile period leads to early maturation of the reproductive neuroendocrine system and puberty by advancing the onset of high-frequency release of gonadotropin-releasing hormone ...
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The Origins and Phenotypic Consequences of Repetitive Sequence Variation in Drosophila melanogaster (2015-08-19)Environmental stimuli can have a significant impact on gene expression patterns and this impact is not always confined to a single cell cycle, but can sometimes persist through multiple divisions or even transgenerationally. ...
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(2017-11-10)Obesity and overweight have become national health concerns and have contributed to many non-communicable or chronic diseases such as type 2 diabetes (T2D), cardiovascular complications, and cancers. A variety of factors, ...
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Prostate Cancer Epigenetic Mechanism Study and Biomarker Discovery Using Bioinformatics Approaches (2021-06-10)Most screening-detected prostate cancer (PCa) is indolent and not lethal. Biomarkers that can predict aggressive diseases independent of clinical features are needed to improve risk stratification of localized PCa patients ...
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(2012-07-16)Chromatin structure is a fundamental determinant of eukaryotic gene expression and it is composed of two chromatin environments, euchromatin and heterochromatin. Euchromatin provides an accessible platform for ...
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(2011-08-08)Pregnane X receptor (PXR) is a ligand-dependent transcription factor that plays an important role in xenobiotic/drug metabolism. The ligand-receptor interaction transcriptionally activates phase I and phase II enzymes, and ...