Now showing items 1-20 of 39

    • Antibodies recognizing a highly expressed putative antigen of CA-MRSA and methods of use 

      Hook, Magnus; Labandeira-rey, Maria; Bowden, Gabriela M. (United States. Patent and Trademark OfficeTexas A&M University. Libraries, 2012-02-28)
      The present invention provides MSCRAMM® proteins from S. aureus which are putative highly-expressed antigens from methicillin-resistant S. aureus, including communit-associated MRSA (CA-MRSA), and these antigens can thus ...
    • Bioinformatic method for identifying surface-anchored proteins from gram-positive bacteria and proteins obtained thereby 

      Hook, Magnus; Xu, Yi; Sillanpaa, Jouko V.; Sthanam, Narayana; Ponnuraj, Karthe; Patti, Joseph M.; Hutchins, Jeff T.; Hall, Andrea; Bowden, Maria G. (United States. Patent and Trademark OfficeTexas A&M University. Libraries, 2010-12-14)
      A bioinformatic method is provided for identifying and isolating proteins with MSCRAMM®—like characteristics from Gram positive bacteria, such as Enterococcus, Staphylococcus, Streptococcus and Bacillus bacteria, which can ...
    • Bioinformatic method for identifying surface-anchored proteins from gram-positive bacteria and proteins obtained thereby 

      Hook, Magnus; Xu, Yi; Sillanpaa, Jouko V.; Sthanam, Narayana; Ponnuraj, Karthe; Patti, Joseph M.; Hutchins, Jeff T.; Hall, Andrea; Bowden, Maria G. (United States. Patent and Trademark OfficeTexas A&M University. Libraries, 2009-11-10)
      A bioinformatic method is provided for identifying and isolating proteins with MSCRAMM®—like characteristics from Gram positive bacteria, such as Enterococcus, Staphylococcus, Streptococcus and Bacillus bacteria, which can ...
    • Carriage of Staphylococcal Toxin Genes and Strain Typing of Isolates from Dogs and Horses 

      Bryan, Laura Katherine (2018-01-17)
      Staphylococcus spp. are important causes of skin and systemic infections in people, dogs, and horses. In dogs, S. pseudintermedius is the most common cause of pyoderma. Staphylococcus aureus exfoliative toxin (ET) genes ...
    • Characterization of Membrane Proteins and Ligand Interactions by Native Ion Mobility Mass Spectrometry 

      Liu, Yang (2019-04-18)
      Membrane proteins interact intimately with the lipid bilayer in which they are embedded. Interactions between membrane proteins and ligands such as lipids and other small molecules can affect protein structure and function. ...
    • Collagen binding protein compositions and methods of use 

      Hook, Magnus; Patti, Joseph M.; House-pompeo, Karen; Sthanam, Narayana; Symersky, Jindrich (United States. Patent and Trademark OfficeTexas A&M University. Libraries, 2001-09-11)
      Disclosed are the cna gene and cna-derived nucleic acid segments from Staphylococcus aureus, and DNA segments encoding cna from related bacteria. Also disclosed are Col binding protein (CBP) compositions and methods of ...
    • Collagen-binding proteins from enterococcal bacteria 

      Rich, Rebecca L.; Kriekemeyer, Bernd; Owens, Rick T.; Hook, Magnus; Murray, Barbara E.; Nallapareddy, Sreedhar R.; Weinstock, George M. (United States. Patent and Trademark OfficeTexas A&M University. Libraries, 2005-06-21)
      A collagen-binding MSCRAMM entitled Ace from enterococcal bacteria is provided which was homologous to the ligand-binding region of Cna, the collagen-binding MSCRAMM from Staphylococcus aureus, and which can be utilized ...
    • Collagen-binding proteins from enterococcal bacteria 

      Rich, Rebecca L.; Kriekemeyer, Bernd; Owens, Rick T.; Hook, Magnus; Murray, Barbara E.; Nallapareddy, Sreedhar R.; Weinstock, George M. (United States. Patent and Trademark OfficeTexas A&M University. Libraries, 2009-12-29)
      A collagen-binding MSCRAMM entitled Ace from enterococcal bacteria is provided which was homologous to the ligand-binding region of Cna, the collagen-binding MSCRAMM from Staphylococcus aureus, and which can be utilized ...
    • Cross-reactive displacing antibodies from collagen-binding proteins and method of identification and use 

      Hook, Magnus; Xu, Yi; Speziale, Pietro; Visal, Livia; Casolini, Fabrizia; Patti, Joseph M.; Patel, Pratiksha; Domanski, Paul (United States. Patent and Trademark OfficeTexas A&M University. Libraries, 2007-07-10)
      Antibodies to the CNA protein and to other regions from the collagen binding domain, including domain CNA19, are provided, and antibodies produced in this manner have been shown to be cross reactive to both Staphylococcus ...
    • Crystal structure of Staphylococcus aureus clumping factor A in complex with fibrinogen derived peptide and uses thereof 

      Hook, Magnus; Ko, Ya-ping; Smeds, Emanuel; Ganesh, Vannakambadi K. (United States. Patent and Trademark OfficeTexas A&M University. Libraries, 2012-10-02)
      The present invention provides a method for determining the structure of a microbial surface components recognizing adhesive matrix molecule in complex with fibrinogen, by providing a ClfA complexed with a fibrinogen ...
    • DbpA compositions 

      Guo, Betty P.; Hook, Magnus (United States. Patent and Trademark OfficeTexas A&M University. Libraries, 2001-04-10)
      Disclosed are the dbp gene and dbp-derived nucleic acid segments from Borrelia burgdorferi, the etiological agent of Lyme disease, and DNA segments encoding dbp from related borrelias. Also disclosed are decorin binding ...
    • DbpA compositions and methods of use 

      Guo, Betty P.; Hook, Magnus (United States. Patent and Trademark OfficeTexas A&M University. Libraries, 2001-11-06)
      Disclosed are the dbp gene and dbp-derived nucleic acid segments from Borrelia burgdorferi, the etiological agent of Lyme disease, and DNA segments encoding dbp from related borrelias. Also disclosed are decorin binding ...
    • Decorin binding protein compositions 

      Guo, Betty; Hook, Magnus (United States. Patent and Trademark OfficeTexas A&M University. Libraries, 2001-05-08)
      Disclosed are the dbp gene and dbp-derived nucleic acid segments from Borrelia burgdorferi, the etiological agent of Lyme disease, and DNA segments encoding dbp from related borrelias. Also disclosed are decorin binding ...
    • Decorin binding protein compositions and methods of use 

      Guo, Betty P.; Hook, Magnus (United States. Patent and Trademark OfficeTexas A&M University. Libraries, 2001-06-19)
      Disclosed are the dbp gene and dbp-derived nucleic acid segments from Borrelia burgdorferi, the etiological agent of Lyme disease, and DNA segments encoding dbp from related borrelias. Also disclosed are decorin binding ...
    • Decorin binding protein compositions and methods of use 

      Guo, Betty; Hook, Magnus (United States. Patent and Trademark OfficeTexas A&M University. Libraries, 1998-12-29)
      Disclosed are the dbp gene and dbp-derived nucleic acid segments from Borrelia burgdorferi, the etiological agent of Lyme disease, and DNA segments encoding dbp from related borrelias. Also disclosed are decorin binding ...
    • Designer collagens and use thereof 

      Russell, Brooke H.; Hook, Magnus; Hahn, Mariah S.; Cosgriff-hernandez, Elizabeth M.; Seo, Neungseon; Xu, Marvin Xuejun (United States. Patent and Trademark OfficeTexas A&M University. Libraries, 2013-12-31)
      The present invention identified a recombinant synthetic collagen containing a triple helical backbone protein produced in a prokaryotic expression system where the protein contains at least one ‘inserted’ biologically ...
    • Designer collagens and use thereof 

      Russell, Brooke H.; Hook, Magnus; Hahn, Mariah S.; Cosgriff-hernandez, Elizabeth M.; Seo, Neungseon; Xu, Marvin Xuejun; Rivera, Jose J.; Browning, Mary Beth (United States. Patent and Trademark OfficeTexas A&M University. Libraries, 2017-08-08)
      The present disclosure provides synthetic collagen and methods of making and using synthetic collagen that include a synthetic collagen that facilitates wound closure comprising an isolated and purified triple helical ...
    • Development of a Multilayer Vascular Graft with Targeted Cellular Interactions and Improved Mechanical Properties 

      Post, Allison Davis (2018-08-15)
      Limited long-term patency of synthetic small diameter vascular grafts has driven considerable research to address their two main failure modes: thrombosis and re-occlusion of the vessel due to intimal hyperplasia. To ...
    • Fibronectin binding protein compositions and methods of use 

      Hook, Magnus; Patti, Joseph M.; House-pompeo, Karen L.; Speziale, Pietro; Joh, Danny; Mcgavin, Martin J. (United States. Patent and Trademark OfficeTexas A&M University. Libraries, 2006-10-31)
      Disclosed are antibodies that block the binding of fibronectin protein to fibronectin. Also disclosed are site specifically-mutated and truncated peptide epitopes derived from the fnbA and fnbB genes of Staphylococcus ...
    • Functional Characterization of NLRC5 and DDX46 in the Regulation of Innate Immune Responses 

      Tong, Yanzheng (2014-04-10)
      The NOD-like receptor protein NLRC5 inhibits TLR-induced NF-ҡB and viral infection-mediated type I interferon signaling in vitro. In the first project, we generated NLRC5 knockout mice to characterize the regulatory function ...